Pkmodel function input | Process | Required parameter | Optional parameter | Excluded parameter |
Administration | Bolus | Tlag, p | Tk0, ka, Ktr, Mtt | |
Zero order absorption | Tk0 | Tlag, p | ka, Ktr, Mtt | |
First order absorption | ka | Tlag, p | Tk0 | |
Absorption with transit compartments of mean transit time Mtt and transit rate Ktr | ka, Ktr, Mtt | Tlag, p | Tk0 | |
Bioavailability; fraction of the dose absorbed | p | Tlag | Tk0, ka, Ktr, Mtt | |
Compartment | Volume | V | ||
Elimination | Linear, rate | ka | Cl, Km, Vm | |
Linear, clearance | Cl | k, Km, Vm | ||
Michaelis Menten | Km, Vm | K, Cl | ||
Transfers | Transfer rates | (k12,k21) (k13, k31 ) |
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Effect compartment transfer rate constant | ke0 | |||
Output | Concentration in the central compartment | first output name | ||
Concentration in the effect compartment | second output name |