Purpose
The goal is to propose an overview of macro input elements as proposed in the following table.
Several points have to be noticed
- Macros are used in the PK: section of the Mlxtran model
- Parameters for a macro call are matched by name, not by ordering
- Default values are given in brackets: for example (0)
- Before concentrations can be used the volumes MUST be defined
- adm and type are equivalent
| Macro input parameters | Macros | ||||||||
| Administration | Compartment | Process | |||||||
| Macro | depot | iv | oral or absorption | compartment | elimination | peripheral | transfer | effect | |
| Identifier | adm (1) | adm (1) | adm (1) | cmt(1) | |||||
| Target | target | cmt(1) | cmt(1) | cmt(1) | target compartments are defined by indices | from(1) to (1) | cmt(1) | ||
| Rates | Required | ka or Tk0 | k or Cl or Vm, Km | (k12, k21), (kij, kji) or (k_i_j, k_j_i) | kt | ke0 | |||
| Optional | ka or Tk0 Tlag (0) Ktr, Mtt (0) |
Tlag (0) | Tlag (0) or Mtt (0), Ktr |
(k13, k31) (k23, k32) |
|||||
| Bioavailability of fraction of the dose absorbed | p (1) | p (1) | p (1) | ||||||
| Volume | volume (1) | volume (1) | |||||||
| Concentration | concentration | concentration | concentration | ||||||
| Amounts | amount | amount | |||||||
| Explanation | No need to define compartments. Used with ODEs |
Target compartment must be defined first Rate or Tinf are taken from data set |
Target compartment must be defined first | Defines compartment and process at the same time | |||||
